Quality of Life in Dogs with Hepatocellular Carcinoma
Understanding quality of life in your dog can help you know what to pay attention to and support informed conversations with your veterinarian.
Quality of life is an important – and often difficult – part of caring for a dog diagnosed with hepatocellular carcinoma (HCC). Medical findings such as imaging results and laboratory values provide important clinical information, but they don’t always capture how a dog is feeling or functioning in everyday life.
Quality of life can look different for every dog. What matters is not only what you observe, but how those observations fit into who your dog is – their usual behavior, routines, favorite activities, and what they enjoy.
Published: April 28, 2026 | Last updated: August 19, 2026
OverviewUnderstanding Quality of LifeQuality of Life ResourcesWhat to ObserveWhat You'll Find Here
This page looks at different parts of a dog’s day-to-day experience that may be helpful to consider when thinking about quality of life. It also brings together selected tools and resources, along with ideas for observing changes over time and organizing what you notice.
The goal is to provide context, support observation, and make it easier to have informed conversations with your veterinarian.
Understanding Quality of Life
Quality of life is generally viewed as a combination of factors instead of a single measurement. Think of it as the many parts that make up a dog’s day-to-day experience – physical comfort, appetite and hydration, energy level, mobility, behavior and interaction, and the presence or absence of clinical signs such as vomiting or diarrhea.AAHA; Hunter and Downing
What “good” or “bad” quality of life looks like can be different for every dog.Fulmer et al. Quality of life isn’t a fixed state and can shift over time.Mondino et al. It can help to think about what is normal and meaningful for your dog and whether those things have changed.Allen
For example, losing interest in food or treats may affect quality of life differently for a dog who has always been a picky eater than for a dog whose favorite part of the day has always been meals and snacks. Similarly, a change in activity may affect quality of life differently for a dog who has always preferred quiet afternoons on the couch than it would for one whose favorite part of the day was going for walks, hiking, or playing.
Factors to Consider When Looking at Quality of Life
Various parts of a dog’s day-to-day experience may provide useful context when thinking about quality of life.AAHA; Hunter and Downing The following are some areas that may be helpful to consider.
Appetite and Hydration
Whether a dog is eating and drinking as usual, or showing changes in interest in food or water.
Energy and Activity
Changes in willingness to move, go for walks, or engage in usual routines.
Comfort
Signs of pain, restlessness, or difficulty settling comfortably.
Mobility
Ability to stand, walk, and change positions.
Behavior and Interaction
Level of engagement with family members, surroundings, and activities that are familiar or meaningful to the dog.
Gastrointestinal Signs
Presence of vomiting, diarrhea, or signs of nausea.
Quality of Life Resources
The following resources reflect different ways quality of life may be considered and discussed in veterinary contexts, each offering a slightly different perspective.
Considering Your Pet’s Quality of Life in the Midst of Disease
A resource from the Colorado State University Veterinary Health System that discusses ways to think about and observe quality of life over time. It includes suggestions such as identifying meaningful activities, tracking good and bad days, and keeping a journal to reflect on changes.
Visit resourceHow to Assess Your Senior Pet’s Quality of Life
A resource from the American Animal Hospital Association that discusses quality of life in senior pets, including factors such as appetite, comfort, cognitive function, mobility, and overall engagement.
Visit resourceHow Will I Know? Assessing Quality of Life and Making Difficult Decisions for Your Pet
A resource from the Ohio State University Veterinary Medical Center Honoring the Bond Program that discusses quality of life in the context of end-of-life decision-making. It includes a worksheet adapted from several veterinary frameworks for evaluating quality of life.
Visit resourceQuality of Life at the End of Life for Your Dog
A VCA Hospitals article that discusses quality of life in dogs approaching the end of life and explains the HHHHHMM scale developed by veterinary oncologist Dr. Alice Villalobos, including the categories hurt, hunger, hydration, hygiene, happiness, mobility, and more good days than bad.
Visit resourceUsing Quality of Life Tools Thoughtfully
Quality of life tools and frameworks can provide structure for observing changes and thinking about different parts of a dog’s day-to-day life. Some use scoring systems, while others focus on questions, observations, or tracking changes over time.
No single tool can capture everything that matters for every dog. When using a quality of life tool, keep in mind that quality of life is subjective and consider observations alongside what you know about your dog – including their usual behavior, their favorite activities, and changes you've noticed. Keeping notes or tracking good and bad days can provide a way to look back and reflect on changesAllen and may also help you recognize patterns, including changes that occur around treatments, medications, or other events.
Quality of life tools do not replace veterinary assessment or judgment. Instead, their role is to help organize observations and support conversations with your veterinarian.
Quality of Life: What to Observe Over Time
When tracking quality of life, it can be helpful to pay attention to a few key areas of your dog’s day-to-day experience over time, especially when changes are gradual.
The following points reflect what was introduced above and are meant to support observation and conversations with your veterinarian, not serve as a checklist or scoring system.
Appetite and Interest in Food
Appetite and interest in food can be an important part of a dog’s day-to-day experience.
Questions to consider:
- Has their appetite or interest in food changed?
- Are they still interested in foods or treats they usually enjoy?
- Are they eating about as much as usual?
Energy and Daily Activity
Energy level can influence how a dog engages with their usual routines and environment.
Questions to consider:
- Are they participating in their usual activities?
- Do they seem more tired or less active than usual?
- Do they tire more easily during activities?
Comfort and Rest
Comfort may be reflected in how easily a dog can settle, rest, and sleep.
Questions to consider:
- Do they appear comfortable when resting?
- Are they able to relax in a way that seems usual for them?
Mobility
Mobility can affect a dog’s ability to move through their environment, perform daily activities, and maintain usual routines, including bathroom habits.
Questions to consider:
- Have you noticed any changes in how easily they move?
- Are they able to stand and walk about as well as usual?
- Are they able to go outside or maintain their usual bathroom habits?
Behavior and Interaction
Changes in behavior and interaction may be noticeable in how a dog engages with family members, their surroundings, and familiar routines.
Questions to consider:
- Are they engaging with family members as usual?
- Do they seem more withdrawn or less interested in interaction?
- Have you noticed any changes in their awareness, routines, or behavior?
Gastrointestinal Signs
Gastrointestinal signs may affect both comfort and overall well-being.
Questions to consider:
- Have you noticed vomiting, diarrhea, or signs of nausea?
- Are these occasional or becoming more frequent?
Enjoyment of Familiar Activities
Interest in familiar activities can be an important part of overall quality of life.
Questions to consider:
- Are they still interested in activities they usually enjoy?
- Are they still able to participate in those activities?
Important:
These observations are not a substitute for veterinary assessment, but they may provide helpful context when discussing your dog’s quality of life with your veterinarian.
Quality of Life Summary Worksheet
Our Quality of Life Summary Worksheet provides a structured way to organize observations about different parts of your dog’s day-to-day life before a veterinary appointment.
View Quality of Life WorksheetAppetite is one area to consider when looking at quality of life and may also come up in discussions about nutrition. For more on this topic, see our pages on nutrition in canine HCC and nutrition resources for dogs with HCC.
Quality of Life in the Context of the Individual Dog
Quality of life can look different for every dog, and it can change over time. When a dog is living with a condition like hepatocellular carcinoma, paying attention to how they are feeling and what they are still able to enjoy can become an especially important part of their care.
Thinking about what is usual and meaningful for your dog – including their comfort, daily routines, and favorite activities – can help you consider quality of life in the context of who your dog is.Allen
You know your dog’s everyday habits and personality in ways that may not always be visible during a veterinary appointment. Sharing what you notice at home can help your veterinarian understand the broader picture and support conversations about your dog’s care.
References
- Allen, Erin. “Considering Your Pet’s Quality of Life in the Midst of Disease.” Colorado State University Veterinary Health System, 6 Aug. 2020, https://csuveterinaryhealth.org/considering-your-pets-quality-of-life-in-the-midst-of-disease/. Accessed 19 Aug. 2026. [CSU]
- American Animal Hospital Association. “How to Assess Your Senior Pet’s Quality of Life.” AAHA, 1 Oct. 2024, updated 16 Dec. 2025, https://www.aaha.org/resources/how-to-assess-your-senior-pets-quality-of-life/. Accessed 19 Aug. 2026. [AAHA]
- Fulmer, Annabelle E., et al. “Quality of Life Measurement in Dogs and Cats: A Scoping Review of Generic Tools.” Animals, vol. 12, no. 3, 8 Feb. 2022, 400. https://doi.org/10.3390/ani12030400. [PMC]
- Hunter, Tammy, and Robin Downing. “Quality of Life at the End of Life for Your Dog.” VCA Animal Hospitals, updated 14 Aug. 2024, https://vcahospitals.com/know-your-pet/quality-of-life-at-the-end-of-life-for-your-dog. Accessed 19 Aug. 2026. [VCA]
- Mondino, Alejandra, et al. “Cross-Sectional and Longitudinal Analysis of Health-Related Quality of Life (HRQoL) in Senior and Geriatric Dogs.” PLOS ONE, vol. 19, no. 9, 4 Sept. 2024, e0301181. https://doi.org/10.1371/journal.pone.0301181. [PMC]